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Q: 2007 Dodge Grand Caravan hard detonation problems

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Caravan has hard detonation problems. Engine lacks power, cannot drive over 40 mph because starts to shake.OBD II Scanner detected engine misfire on cylinders 1, 3 (back) and 4 (front). So far have replaced sparks plugs (#4 was burned), spark plugs wires, ignition coil, knock sensor, TPS, Crankshaft Sensor and poured Cataclean into the tank. Two weeks later poured B-12 Chemtool (2 bottles), problem persists.

My car has 180000 miles.
My car has an automatic transmission.

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